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And I go up five milligrams, four days after my initial dose, because the methadone starts to wear off around sixteen or eighteen hours after I'm dosed, and I'm a shaking sweaty irritable mess by the time I walk into the clinic. I should have gone up sooner, but my stomach needed time to adjust, as did my brain. My daily unshakable habit invilved me doing 2.5-10 milligrams of oxycodone at a time, repeat and repeat all day long. Taking thirty five milligrams of methadone is like taking 67.5 milligrams of oxycodone, all at once. It has a tendancy to knock me flat on my ass.